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The Positive and Negative Syndrome Scale for Schizophrenia Autism Severity Scale (PAUSS) in a sample of early-onset psychosis
- J. Suárez Campayo, L. Pina-Camacho, J. Merchán-Naranjo, C. Ordas, V. Cavone, R. Panadero, G. Sugranyes, I. Baeza, J. Castro-Fornieles, E. de la Serna, C. Arango, C. M. Diaz Caneja
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- Journal:
- European Psychiatry / Volume 66 / Issue S1 / March 2023
- Published online by Cambridge University Press:
- 19 July 2023, pp. S443-S444
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Introduction
The Positive and Negative Syndrome Scale for Schizophrenia Autism Severity Scale (PAUSS) scale can be derived from the Positive and Negative Schizophrenia Syndrome Scale, enabling an assessment of psychotic and autistic dimensions with a single tool.
ObjectivesThe aim of the study was to investigate the prevalence of autistic traits and the diagnostic, developmental, clinical, and functional correlates of this phenotype in a sample of early-onset psychosis (onset before age 18 years; EOP).
MethodsProspective observational 2 year- follow-up study in a sample of young people with a first-episode of EOP. Demographic, perinatal, developmental, cognitive, clinical, and functional data were collected. PAUSS total scores and socio-communication and repetitive behaviors subscores were calculated. We used the proposed cut-off points for adult populations to define prevalence of autistic traits (PAUSS≥30). Subgroups of patients with and without autistic traits were identified based on the total PAUSS terciles. We used the Cronbach’s alpha test to assess the PAUSS internal consistency. Linear mixed models were performed to compare changes in PAUSS during follow-up between diagnostic subgroups [i.e., non-affective psychosis (including schizophrenia and schizophreniform disorder), affective psychosis (including bipolar disorder, schizoaffective disorder and major depressive disorder with psychotic features), and other psychosis (including brief psychotic disorder and psychosis not otherwise specified)]. Developmental, clinical, and functional variables were compared between subgroups with and without autistic traits with logistic regression analysis.
Results248 patients with PIT were included (age 15.69 ± 1.86 years, 38.65% female). The prevalence of autistic traits in EOP was 7.04%, with significantly higher prevalence in the group of patients with non-affective psychosis (15.20%) than in other diagnostic groups. PAUSS scores significantly decreased over time, with no significant differences in the trajectories of the total PAUSS and its subscores among the three diagnostic subgroups during the 2-year follow-up. The PAUSS showed good internal consistency at all visits (Cronbach’s alpha > 0,88). Patients with autistic traits presented longer duration of untreated psychosis, longer duration of the first inpatient admission, poorer social adjustment in childhood, poorer functionality, greater clinical severity, and poorer response to treatment during follow-up than patients without autistic traits.
ConclusionsThe PAUSS is an easy-to-apply tool that can be useful to differentiate psychosis subgroups with worse prognosis.
Disclosure of InterestJ. Suárez Campayo: None Declared, L. Pina-Camacho: None Declared, J. Merchán-Naranjo: None Declared, C. Ordas: None Declared, V. Cavone: None Declared, R. Panadero: None Declared, G. Sugranyes: None Declared, I. Baeza: None Declared, J. Castro-Fornieles: None Declared, E. de la Serna: None Declared, C. Arango Consultant of: Acadia, Angelini, Gedeon Richter, Janssen Cilag, Lundbeck, Minerva, Otsuka, Roche, Sage, Servier, Shire, Schering Plough, Sumitomo Dainippon Pharma, Sunovion and Takeda, C. Diaz Caneja Grant / Research support from: Exeltis and Angelini
Pre-earthquake Burden of Illness and Postearthquake Health and Preparedness in Veterans
- Claudia Der-Martirosian, Deborah Riopelle, Diana Naranjo, Elizabeth M. Yano, Lisa V. Rubenstein, Aram Dobalian
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- Journal:
- Prehospital and Disaster Medicine / Volume 29 / Issue 3 / June 2014
- Published online by Cambridge University Press:
- 10 April 2014, pp. 223-229
- Print publication:
- June 2014
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Background
During an earthquake, vulnerable populations, especially those with chronic conditions, are more susceptible to adverse, event-induced exacerbation of chronic conditions such as limited access to food and water, extreme weather temperatures, and injury. These circumstances merit special attention when health care facilities and organizations prepare for and respond to disasters.
MethodsThis study explores the relationship between pre-earthquake burden of illness and postearthquake health-related and preparedness factors in the US. Data from a cohort of male veterans who were receiving care at the Sepulveda Veterans Affairs Medical Center (VAMC) in Los Angeles, California USA during the 1994 Northridge earthquake were analyzed.
ResultsVeterans with one or more chronic conditions were more likely to report pain lasting two or more days, severe mental/emotional stress for more than two weeks, broken/lost medical equipment, having difficulty refilling prescriptions, and being unable to get medical help following the quake compared to veterans without chronic conditions. In terms of personal emergency preparedness, however, there was no association between burden of illness and having enough food or water for at least 24 hours after the earthquake.
ConclusionThe relationship that exists between health care providers, including both individual providers and organizations like the US Department of Veterans Affairs (VA), and their vulnerable, chronically-ill patients affords providers the unique opportunity to deliver critical assistance that could make this vulnerable population better prepared to meet their postdisaster health-related needs. This can be accomplished through education about preparedness and the provision of easier access to medical supplies. Disaster plans for those who are burdened with chronic conditions should meet their social needs in addition to their psychological and physical needs.
. ,Der-Martirosian C ,Riopelle D ,Naranjo D ,Yano E ,Rubenstein L .Dobalian A Pre-earthquake Burden of Illness and Postearthquake Health and Preparedness in Veterans . Prehosp Disaster Med.2014 ;29 (3 ):1 -7
How many meals a day to minimize cannibalism when rearing larvae of the Amazonian catfish Pseudoplatystoma punctifer? The cannibal’s point of view
- Etienne Baras, Dustin V. Silva del Aguila, Grace V. Montalvan Naranjos, Rémi Dugué, Fred Chu Koo, Fabrice Duponchelle, Jean-François Renno, Carmen Garcia-Dávila, Jesus Nuñez
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- Journal:
- Aquatic Living Resources / Volume 24 / Issue 4 / October 2011
- Published online by Cambridge University Press:
- 03 November 2011, pp. 379-390
- Print publication:
- October 2011
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Meal frequency is a key parameter in fish larviculture, especially in highly cannibalistic species. Knowledge of the biological bases of cannibalism (growth capacity of cannibals, morphological constraints on cannibalism, prey size preference) can help predicting the risks of cannibalism for different feeding schedules under culture conditions. This study relied on the day-by-day analysis of prey size preference and bioenergetics of individual cannibals of the catfish Pseudoplatystoma punctifer (8–65 mm standard length, SL, 0.5–400 mg dry mass, DM) at 28.5 °C under 12L:12D. The results were equated with the ontogenetic variations of morphological factors (head and mouth width) and feed efficiency of larvae feeding on Artemia nauplii, in order to calculate the risks of cannibalism among fish fed 2–7 daily meals. The predation capacities of P. punctifer were highest at 8 mm SL and decreased in larger fish (largest prey = 86% and 70% SL in fish of 8 and >30 mm SL, respectively). Cannibals of increasing size preferred increasingly smaller prey relative to their own size, but also to their predation capacities. These morphological and behavioural constraints were largely compensated for by bioenergetics performance. Cannibals consumed high daily food rations (as high as 171 and 29% DM in fish <1 and >300 mg DM, respectively), exhibited high gross conversion efficiencies (0.50–0.55 and about 0.70, in fish <1 and >30 mg DM, respectively), and grew rapidly (90 and 18% DM day-1 in fish <1 and >300 mg DM, respectively). The growth advantage of cannibals over siblings fed Artemia nauplii was decisive, except for high meal frequencies (6–7 daily meals). This study supports the view that the risk of cannibalism and adequate feeding strategies can be largely predicted in a particular fish species if the morphological, behavioural and bioenergetics bases of cannibalism are examined altogether in an ontogenetic perspective.
Morphological, structural and textural variations in the 1988–1990 andesite lava of Lonquimay Volcano, Chile
- J. A. Naranjo, R. S. J. Sparks, M. V. Stasiuk, H. Moreno, G. J. Ablay
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- Journal:
- Geological Magazine / Volume 129 / Issue 6 / November 1992
- Published online by Cambridge University Press:
- 01 May 2009, pp. 657-678
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The 1988–1990 eruption of Lonquimay Volcano, Chile (38°S) formed a 10.2 km long andesite lava with a volume of 0.23 km3 over a period of 13 months. The lava extrusion rate decreased with time as chamber pressure and vent dimensions decreased. The velocity of the flow front decreased exponentially with distance from vent as a consequence of cooling and the increase of apparent viscosity at the flow front. The lava developed a central channel which decreased in width and depth with time. Three prominent lava levées were formed on each margin and resulted from abandonment as the channel decreased in width as a result of a rapid decrease of flow rate over the first 100 days of activity. A fourth major levée developed in February, during a brief period of flow rate increase down the main channel, but its walls were gradually exposed as the lava depth again decreased due to declining flow rate. The structure of lava levées depended on their age and longevity of the flow in the adjacent channel. Initial levées were formed in the first few days as the lava spread laterally and then retreated, leaving levées of massive lava. More mature rubble levées were formed during the next month by the lava pushing and then shearing aa and blocky breccia which formed on the cooling flow margin. Fragmentation and abrasion formed a characteristic zonation in the levées. A basal zone consists of very poorly sorted matrix-rich breccia with very rounded vesicular clasts and bimodal grain size distribution. The basal breccia zone strongly resembles block and ash flow deposits. This zone passes up into a zone of clast-supported clinker breccia which becomes increasingly matrix-poor and coarser with clasts becoming more angular upwards. The crest of the levée is composed of large (10–100 cm) angular to subangular blocks with no matrix. The zoned levées form after the active lava channel suddenly narrows. Lava depth initially increases and breccias are deposited on the channel margins and acquire the zoned structure by progressive shearing and accretion of clinkery aa breccia. The lava level then drops exposing the steep inner scarp of a levée. The most mature levée type formed in a long-lived channel over several months. The outer wall of the levée consists of zoned breccia, but the inner wall consists of a massive curving wall of strongly foliated lava with well-developed horizontal striations and ductile Reidel shears. The massive foliated facies is a consequence of prolonged flow which coats strongly sheared lava onto the inner levée wall. Scanning electron microscopy shows that the aa clinker clasts and foliated lava from the levée walls form at low melt fractions (⋚ 15%). In the last three months of the eruption the flow front ceased to advance but thickened as lava drained from proximal regions and intruded into the interior of the distal lava. The last stages of lava movement were characterized by updoming in the central channel. A lava surface feature, named here ‘Armadillo structure’, was formed by deformation of the cooler but still ductile lava crust. The deformation caused by underflow produced Reidel shears dipping upstream and doming of the lava due to rotation of the shear planes. The study demonstrates that lava morphology, structure and texture are strongly influenced by variations of effusion rate, local flow rate, channel topography and thermal maturity of the lava, which is reflected in downstream changes in viscosity.
GRAVITY: microarcsecond astrometry and deep interferometric imaging with the VLTI
- F. Eisenhauer, G. Perrin, C. Straubmeier, W. Brandner, A. Boehm, F. Cassaing, Y. Clenet, K. Dodds-Eden, A. Eckart, P. Fedou, E. Gendron, R. Genzel, S. Gillessen, A. Graeter, C. Gueriau, N. Hamaus, X. Haubois, M. Haug, T. Henning, S. Hippler, R. Hofmann, F. Hormuth, K. Houairi, S. Kellner, P. Kervella, R. Klein, J. Kolmeder, W. Laun, P. Lena, R. Lenzen, M. Marteaud, D. Meschke, V. Naranjo, U. Neumann, T. Paumard, M. Perger, D. Perret, S. Rabien, J. R. Ramos, J. M. Reess, R. R. Rohloff, D. Rouan, G. Rousset, B. Ruyet, M. Schropp, B. Talureau, M. Thiel, J. Ziegleder, D. Ziegler
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- Journal:
- Proceedings of the International Astronomical Union / Volume 3 / Issue S248 / October 2007
- Published online by Cambridge University Press:
- 01 October 2007, pp. 100-101
- Print publication:
- October 2007
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We present the adaptive optics assisted, near-infrared VLTI instrument GRAVITY for precision narrow-angle astrometry and interferometric phase referenced imaging of faint objects. With its two fibers per telescope beam, its internal wavefront sensors and fringe tracker, and a novel metrology concept, GRAVITY will not only push the sensitivity far beyond what is offered today, but will also advance the astrometric accuracy for UTs to 10 μas. GRAVITY is designed to work with four telescopes, thus providing phase referenced imaging and astrometry for 6 baselines simultaneously. Its unique capabilities and sensitivity will open a new window for the observation of a wide range of objects, and — amongst others — will allow the study of motion within a few times the event horizon size of the Galactic Center black hole.
Prevalence of infection and 18S rRNA gene sequences of Cytauxzoon species in Iberian lynx (Lynx pardinus) in Spain
- J. MILLÁN, V. NARANJO, A. RODRÍGUEZ, J. M. PÉREZ DE LA LASTRA, A. J. MANGOLD, J. DE LA FUENTE
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- Journal:
- Parasitology / Volume 134 / Issue 7 / July 2007
- Published online by Cambridge University Press:
- 28 February 2007, pp. 995-1001
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The Iberian lynx (Lynx pardinus) is the most endangered felid in the world. Only about 160 individuals remain in 2 separate metapopulations in Southern Spain (Sierra Morena and Doñana). We obtained blood samples of 20 lynxes captured from 2004 to 2006, and determined the prevalence of infection and genetic diversity of Cytauxzoon spp. using 18S rRNA PCR and sequence analysis. Prevalence of infection was 15% (3 of 20). Cytauxzoon sp. was only detected in Sierra Morena. For phylogenetic analysis, we used the sequences reported in the present study and those characterized in different domestic and wild felids and ticks from North and South America, Asia and Europe. Three different Cytauxzoon sp. sequences were obtained. They were closely related to that obtained from a Spanish cat, but diverged in up to 1·0% with respect to the only previously reported sequence from an Iberian lynx. Conversely, the latter sequence clustered together with C. manul sequences obtained from Pallas cats (Otocolobus manul) in Mongolia. Our analysis yields a separate cluster of C. felis sequences from cats, wild felids and ticks in the United States and Brazil. These results suggest that at least 2 different Cytauxzoon spp. may be present in Iberian lynx. The apparent absence in one of the areas, together with the possibility of fatal cytauxzoonosis in lynxes makes necessary disease risks to be taken into account in management conservation strategies, such as translocations and re-introductions.